I'm always very wary about fucking the intoxicated. I knew a girl who was a total slut when she got drunk and then literally every time she fucked a guy, she'd tell me she thought she was raped. This happened seriously no less than 10 times before she finally just realized she was a whore. On the other hand, if its someone you can actually trust, get high as a fucking kite and hit it like its never been hit before.