Age of Marijuana Use and Psychosis

[Latrinsorm]

Dr. Cox

I assume we agree that this is your post, and this is the study cited therein. Stated in that study:

"The incidence of serious gastrointestinal complications has been estimated to be in the order of one case per 1,000 persons per year, with a fatality rate around 5–10 percent. This incidence was around two and four times higher for users of aspirin and nonaspirin NSAIDs, respectively."

1 per 1000 * 7.5% = .075 per 1000 without aspirin
.075 per 1000 * 3 = .215 per 1000 with aspirin
.215 - .075 = .145 per 1000 caused by aspirin = 1.45 per 10,000 caused by aspirin
rounds off to 1 per 10,000

No?

[Mighty Nikkisaurus]

You've lost me on the first two, but it's certainly plausible that people who are ill could suffer other side effects. Do you have any specific ones in mind, for any of the drugs we're talking about?

Comorbidity is a thing. Reputable studies will account for it. Funny though, almost every drug study won't.

Why would I want to f*** myself? My hair's not that amazing. Okay, well it is, but... what were we talking about?

I'm glad you think it's amusing. It's not to me, or my family. Detoxing from booze and having a seizure wasn't funny, either, but I guess I just don't have a good sense of humor. Looking at my sleeping child and pleading internally that I get to watch him grow up and not die because of my illness or addiction, really hilarious. Following doctor's protocol and behaving in a frightening way with a total mental black out... very LOL. How hilarious.

My point is not that alcohol provides more benefit than marijuana, I would guess it provides less although I haven't seen either's analgesic potential quantified. My point is that the risk of marijuana is more more than the benefit of alcohol is less, which is why I think it's so important to quantify when we can.

What is the benefit of alcohol? What can you possibly tell me alcohol is good for? Most people don't become addicted to it but most of the people who do have pasts that consist of being abused and traumatized? Wow, yay! What a great thing to protect.

You absolutely ARE a hypocrite. You'll hold up a drug that causes absolutely horrific harm (go to a week's worth of AA meetings then get back to me if you disagree) but slap at a drug that has minor potential complications.

I'm happy you're able to happily hold your position. Meanwhile, I got to have a long 4 hour sit down with my husbands work because I want to not suffer from the effects of PTSD my whole life. I got to spill my life story to strangers, have a urine and hair check, get attached to a bunch of shit for a lie detector test, all because I'm going to try to get my PTSD cured by MDMA. The only reason my husband won't lose clearance is because I live in a state that protects this sort of thing. Yeah, pardon me for thinking that's fucked and really not liking people like you.

[Androidpk]

Let me know how the MDMA treatment goes. I've been hearing good things about it in regards to PTSD treatment. Psilocybins too.

[Parkbandit]

Comorbidity is a thing. Reputable studies will account for it. Funny though, almost every drug study won't.



I'm glad you think it's amusing. It's not to me, or my family. Detoxing from booze and having a seizure wasn't funny, either, but I guess I just don't have a good sense of humor. Looking at my sleeping child and pleading internally that I get to watch him grow up and not die because of my illness or addiction, really hilarious. Following doctor's protocol and behaving in a frightening way with a total mental black out... very LOL. How hilarious.



What is the benefit of alcohol? What can you possibly tell me alcohol is good for? Most people don't become addicted to it but most of the people who do have pasts that consist of being abused and traumatized? Wow, yay! What a great thing to protect.

You absolutely ARE a hypocrite. You'll hold up a drug that causes absolutely horrific harm (go to a week's worth of AA meetings then get back to me if you disagree) but slap at a drug that has minor potential complications.

I'm happy you're able to happily hold your position. Meanwhile, I got to have a long 4 hour sit down with my husbands work because I want to not suffer from the effects of PTSD my whole life. I got to spill my life story to strangers, have a urine and hair check, get attached to a bunch of shit for a lie detector test, all because I'm going to try to get my PTSD cured by MDMA. The only reason my husband won't lose clearance is because I live in a state that protects this sort of thing. Yeah, pardon me for thinking that's fucked and really not liking people like you.

[Fallen]

Glad to hear you're enrolled in such a study, Nikki. I donate regularly to MAPS, which does absolutely fantastic work. Are you in any way affiliated with them?

[Mighty Nikkisaurus]

Let me know how the MDMA treatment goes. I've been hearing good things about it in regards to PTSD treatment. Psilocybins too.

I am super hopeful. They only recently opened things up to non-combat PTSD sufferers. I've been having twice a month talks with a therapist they have provided via Skype. I really, really hope this makes things better. As far as I know we do a session where I revisit my trauma, and then we do an altered session where I revisit the trauma with MDMA in my system. So many people are cured after this... I don't want to hope for too much but I desperately want to be cured. I hate the grip that PTSD has on my life.

[Androidpk]

I am super hopeful. They only recently opened things up to non-combat PTSD sufferers. I've been having twice a month talks with a therapist they have provided via Skype. I really, really hope this makes things better. As far as I know we do a session where I revisit my trauma, and then we do an altered session where I revisit the trauma with MDMA in my system. So many people are cured after this... I don't want to hope for too much but I desperately want to be cured. I hate the grip that PTSD has on my life.

Incoming PMS.

[Mighty Nikkisaurus]

Glad to hear you're enrolled in such a study, Nikki. I donate regularly to MAPS, which does absolutely fantastic work. Are you in any way affiliated with them?

MAPS is amazing. My husband works for a government contractor and they helped me navigate through all of the paper work to make sure his clearance doesn't get revoked. They also provided me information of others who underwent the study I'm scheduled to go through, so I have a lot of "friends" and people who get what it's like to live with PTSD, the nightmares, etc but also have recovery experience. '

MAPS is just fantastic. I encourage anyone to donate to them. They help people and provide hope that otherwise doesn't exist.

[Latrinsorm]

CBD, despite any attempts to vilify it by saying it has the same side effects of a different drug (with no proof or evidence whatsoever)has yet to be shown to have any withdrawal symptoms.

http://www.medicinalgenomics.com/wp-...aschi_2011.pdf

It's ironic that those so worried about schizophrenia would seek to mindlessly dismiss one of the most promising treatments for the disease to appear in years.

I do not vilify or dismiss. I merely quote from your source. Do you dispute that CBD has a pharmacological profile similar to clozapine, and that clozapine has withdrawal symptoms that include psychosis? Your new source's only mention of withdrawal effects is that one 19-year-old didn't have them.

Comorbidity is a thing. Reputable studies will account for it. Funny though, almost every drug study won't.

Can you be more specific about what effect that would have in this case? That is: are the risks of Zoloft are higher or lower than the stated values, are the risks of marijuana higher or lower? In general, would comorbidity have a different effect from drug to drug?

I'm glad you think it's amusing. It's not to me, or my family. Detoxing from booze and having a seizure wasn't funny, either, but I guess I just don't have a good sense of humor. Looking at my sleeping child and pleading internally that I get to watch him grow up and not die because of my illness or addiction, really hilarious. Following doctor's protocol and behaving in a frightening way with a total mental black out... very LOL. How hilarious.

The joke is that I too suffer from mental illness. See? Funnier now, right?

What is the benefit of alcohol? What can you possibly tell me alcohol is good for? Most people don't become addicted to it but most of the people who do have pasts that consist of being abused and traumatized? Wow, yay! What a great thing to protect.

Recreation is a benefit for both alcohol and marijuana.

You absolutely ARE a hypocrite. You'll hold up a drug that causes absolutely horrific harm (go to a week's worth of AA meetings then get back to me if you disagree) but slap at a drug that has minor potential complications.

I don't really follow you here either. You react quite negatively to someone making a joke related to mental illness, but then dismiss it as "minor potential complications". You request studies and objective evidence for a drug's harmfulness, but then tell me to go to AA meetings. I make no judgment as to the appropriateness of any of these four positions, I'm just trying to figure out where you stand.

Have you ever noticed how frequently people who agree with you accuse people who agree with me of hypocrisy? I'm sure I don't need to inform you of the definition, so isn't it possible that I honestly believe marijuana to be worse than alcohol? Why is it so important that I be labeled a hypocrite, as opposed to simply wrong?

[Fallen]

Studies in Humans

In human studies, CBD administration did not induce side effects across a wide range of dosages, including acute and chronic dose regimens, and tolerance to CBD did not develop.

Acute Studies In the 1970s, human studies showed that oral CBD intake from 15 to 160mg [61-63], inhalation of 0.15mg/kg bw [64]or intravenous injection from 5 to 30mg [4][61] were not followed by ill effects.

CBD does not interfere with several psychomotor and psychological functions in humans. CBD does not affect heart rate, blood pressure, or performance in the verbal paired-associate learning test as measured by recall score at doses up to 600mg [5][62][65][74].

Subsequent studies concerning the antipsychotic effects of CBD have not reported any side effects after CBD intake[75-77].

Chronic Studies Chronic oral administration of 10mg CBD daily for 21 days did not induce any changes in neurological (including electroencephalogram (EEG)), clinical (including electrocardiogram (EKG)), psychiatric, blood or urine examinations [78].

Likewise, oral CBD administration in healthy participants (3mg/kg bw daily for 30 days) and in epileptic patients (200-300mg daily for 135 days) was well tolerated and no signs of toxicity or serious side effects were detected on neurological and physical examinations, blood and urine analysis, or EKG and EEG, which were performed at weekly intervals [10].

CBD was evaluated for symptomatic efficacy and safety in 15 neuroleptic-free patients with Huntington's Disease.Effects after oral CBD (10mg/kg bw /day for 6 weeks) or placebo (sesame oil for 6 weeks) intake were evaluated weekly under a double-blind, randomized crossover design.

CBD showed no significant or clinical differences compared to placebo in the Cannabis side effect inventory, clinical lab tests or other safety outcome variables. Also, weekly plasma levels of CBD (mean range 5.9 to 11.2 ng/ml), assayed by GC/MS, did not differ significantly over the 6 weeks of CBD administration [79].

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