Anyone here deployed large clusters to these services?

Specifically I am looking to see if there has been an increase in performance in drives.

I made a 10TB volume in Windows 2008 using the new volume structures, but found you are limited to 12 drives through that system.

So I would like to use S3, but I am not sure if I can simply map S3 as a drive and then tell IIS to send the files out from that folder.

The last time I used S3 like that the number of requests simply bogged down to the point it was not worth the expense.