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Competing interests: There are no actual or potential conflicts of interest including any financial, personal, or other relationships with other people or organizations within 3 years of beginning the work submitted that could inappropriately influence (bias) their work. No author’s institution has contracts relating to this research through which it or any other organization may stand to gain financially now or in the future. There are no other agreements of authors or their institutions that could be seen as involving a financial interest in this work. The data contained in the manuscript being submitted have not been previously published, have not been submitted elsewhere and will not be submitted elsewhere.